Fast dissolving tablets have been improved the disintegration of tablets so ultimately increase the bioavailability of the drug. Tizanidine is a centrally acting α-2 adrenergic agonist. Here in present study fast dissolving tablets of Tizanidine HCl prepared by using superdisintegrating agents such as crospovidone, crosscarmellose, sodium starch glycolate. Crosscarmellose has less disintegration time as compared to other polymer due to its wicking type of mechanism and capillary action. Crospovidone has a higher disintegration time compared to other polymer. Combinations of polymer have better effects than single polymer. Formulation F9 which formulated by polymers Crosscarmellose and SSG were established to be the optimum formulation because of higher wetting ratio and less disintegration time.
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